Jeffrey I. Cohen

Transgene expression kinetics and replication potential of recombinant adenovirus serotype 4 in a mouse model and its use as a herpes simplex virus vaccine

Human adenovirus serotype 4 (Ad4) is used as a replication-competent oral vaccine that safely and effectively prevents Ad4 respiratory illness in US military personnel. Recombinant Ad4 vaccine candidates elicit mucosal and systemic immune responses against respiratory viruses in...

Dengue virus controlled human challenge reveals that preexisting immunity shapes viral replication and broadly protective responses

Dengue is the canonical viral disease for which immune history is a determinant of protective versus pathogenic responses and immunogenicity. Yet, because of limitations in animal models and clinical presentation after peak viremia, how preinfection and early immune responses aff...