Jeffrey D. Mighion

Enantioselective Benzylic C–H Insertions with Diazosuccinate Esters

Abstract The first enantioselective benzylic C–H insertion using α-alkyl-α-diazoesters, facilitated by a well-established chiral dirhodium(II) catalyst, is presented. This reaction selectively functionalizes primary benzylic C–H bonds with good to excellent enantioselectivity (up...