Jeffrey Benjamin

Acidic Phytocannabinoids as Endocannabinoid System Vitamers: A Formal Nutritional Hypothesis and Its Failure Conditions

This manuscript advances a formal, falsifiable nutritional hypothesis: that acidic phytocannabinoids (Δ9-tetrahydrocannabinolic acid, cannabidiolic acid, cannabigerolic acid, and related family members) constitute a candidate vitamer family supporting endocannabinoid system (ECS)...

Acidic Phytocannabinoids as Endocannabinoid System Vitamers: A Formal Nutritional Hypothesis and Its Failure Conditions

This manuscript advances a formal, falsifiable nutritional hypothesis: that acidic phytocannabinoids (Δ9-tetrahydrocannabinolic acid, cannabidiolic acid, cannabigerolic acid, and related family members) constitute a candidate vitamer family supporting endocannabinoid system (ECS)...

Everyone Had Something Right: A Historiographical Reassessment of THCA-A/CB1 Receptor Pharmacology

The claim that phytocannabinoids other than THC are pharmacologically inert at CB1 and CB2 rests on a body of receptor-binding literature that is usually described, when it is discussed at all, as "contradictory." This piece traces that literature — beginning with the isolation o...

Stomach Acid, Blood pH, and Liver Metabolism: The Stability and Transformation of Acidic Cannabinoids

Acidic cannabinoids (e.g., THCA, CBDA) are the dominant phytoconstituents in Cannabis sativa L. and serve as precursors to neutral forms (THC, CBD) via decarboxylation. This is the third work in an integrated series exploring how dietary cannabis inputs interact with Endocannabin...

Stomach Acid, Blood pH, and Liver Metabolism: The Stability and Transformation of Acidic Cannabinoids

Acidic cannabinoids (e.g., THCA, CBDA) are the dominant phytoconstituents in Cannabis sativa L. and serve as precursors to neutral forms (THC, CBD) via decarboxylation. This is the third work in an integrated series exploring how dietary cannabis inputs interact with Endocannabin...