Jeffery L. Twiss

An axon-intrinsic loop restricts nerve regeneration through axonal protein synthesis

ABSTRACT Injured axons synthesize the RNA Binding Protein KHSRP that promotes mRNA decay and slows nerve regeneration. Axotomy-induced increase in axoplasmic Ca 2+ activates axonal Khsrp translation, and while Ca 2+ returns to pre-injury levels within 16 hours post-axotomy, axona...