Jeetain Mittal

Molecular Details of RNA Interactions With FUS Condensates Altering Assembly, Dynamics, and Aggregation

ABSTRACT Fused in sarcoma (FUS) is an RNA‐binding protein that undergoes phase separation with RNA and other cellular components, forming ribonucleoprotein (RNP) granules. While recent advances in the study of biomolecular phase separation have focused on protein–protein interact...

Ki-67 regulates heterochromatin organization in neurons and forms condensates with heterochromatic components

Abstract The dysregulation of chromatin organization has been associated with numerous forms of neurological disease. In the ANAPC7 neurodevelopmental syndrome, a disease mechanistically linked to defective proteasomal degradation, the mitotic protein Ki-67 accumulates abnormally...