Jean Christophe Poncer

Differential isoform-specific control of KCC2 function in developing and mature cortical neurons

Abstract The K-Cl cotransporter KCC2 is essential for fast synaptic inhibition in the mature brain. It is encoded by a single gene and expressed as two isoforms: KCC2a and KCC2b, which differ in their N-terminal domains. While KCC2b is predominant, the function of the weakly expr...