Jay P. McLaughlin

Epigenetic LOCK chromatin links H3K9 modifications to ATM–γH2AX signaling in HIV-Tat and opioid neuroinflammation

Abstract HIV-Tat and morphine synergistically exacerbate neuroinflammation and DNA damage, yet the mechanisms linking the DNA damage response (DDR), chromatin remodeling, and innate immune activation remain poorly understood. Here, we investigated how HIV-Tat and morphine alter D...