Javier Martínez Mellado

EBNA2-Driven X Chromosome Amplification and LTB-NF-kB Feedback Explain the 9:1 Female Predominance and Glandular Tropism of Sjogren Syndrome

Sjogren syndrome is a systemic autoimmune disease characterized by lymphocytic infiltration of salivary and lacrimal glands, affecting women 9 times more than men. The etiology of this sex bias and the glandular tropism have remained unexplained. We integrate the largest Sjogren...