Janine Altmüller

Human hair–bearing skin organoids reveal cell type–specific susceptibility and innate immune responses to herpes simplex virus 1

Epithelial surfaces are the primary sites of lytic herpes simplex virus 1 (HSV-1) infection following initial exposure or reactivation from latency. To model this complex environment, we used human hair–bearing skin organoids and combined single-cell spatial transcriptomics with...

HSAT3 lncRNA regulates replication re-initiation and colocalizes with TOP2A under stress conditions

Abstract Background Long non-coding RNAs transcribed from pericentromeric Satellite 3 repeats ( HSAT3 ) are involved in stress-dependent splicing processes and maintenance of genome stability. The functions of the transcripts are largely unknown, which is mainly due to the predom...

Deep molecular profiling of lung neuroendocrine tumours and supra-carcinoids

BACKGROUND: Lung neuroendocrine tumours (NETs, also known as carcinoids) are rapidly rising in incidence worldwide but have unknown aetiology and limited therapeutic options beyond surgery. The current WHO classification, based on mitotic count and presence or absence of necrosis...