Jane M. Blazeby

A metabolomic signature of weight-loss and its associations with BMI-linked diseases: A post-hoc analysis of two intervention trials and a mendelian randomisation study

Abstract Background Obesity is a major risk factor for heart failure (HF), but the molecular mediators linking adiposity to HF remain unclear. The molecular mechanisms by which weight loss reduces the risk of HF are also unknown. Understanding these mechanisms could highlight pot...