Jan Grijpstra

Rationally designed FimH variants with enhanced functional immunogenicity as vaccine candidates for ExPEC urinary tract infections

Abstract Extraintestinal pathogenic Escherichia coli (ExPEC) is a major cause of urinary tract infections (UTIs) and invasive disease. Rising antimicrobial resistance highlights the need for preventive strategies such as vaccination. The conserved D-mannose-specific adhesin FimH...