Jamieson A. L. Howard

Differential detection of tau aggregation species using a small molecule probe for cell-based drug screening

Tau aggregation into polymorphic species, including oligomers, fibrils, and neurofibrillary tangles (NFTs), is central to the pathology of Alzheimer’s disease and related tauopathies. As an intrinsically disordered protein, tau undergoes liquid-liquid phase separation (LLPS), a m...