James Y. Hamilton

Accelerated Hit Identification and Optimization of a Novel Class of Cellularly Active QPCT/L Inhibitors

Abstract QPCT and its Golgi-bound analogue QPCTL catalyze the conversion of N-terminal glutamines into pyroglutamates, a modification that influences diverse biological processes, including Aβ oligomerization, chemokine stabilization, and CD47-SIRPα signaling. Consequently, QPCT/...