JAMES M. SPENCER

Hydration Changes are Essential for Efficient Breakdown of Faropenem by the L1 Metallo-β-lactamase

Abstract Metallo-β-lactamases (MBLs) are key contributors to antimicrobial resistance (AMR). The L1 MBL, originally from Stenotrophomonas maltophilia, is a tetrameric, dizinc, subclass B3 MBL that efficiently hydrolyzes most β-lactam antibiotics and evades inhibitors that act on...