James B. Thissen

Developing and benchmarking one health genomic surveillance tools for influenza A virus in wastewater

Abstract Influenza A viruses (IAV) remain a persistent One Health threat, and whole-genome sequencing from wastewater offers a promising surveillance tool. However, IAV is at low abundance in wastewater, making it difficult to sequence. We benchmark four targeted enrichment metho...

Hierarchical sparse Bayesian multitask learning for disease prediction in pooled microbiome studies

Abstract Background: Microbiome-based disease prediction across pooled studies is challenging because the data are high dimensional, heterogeneous, and often too limited to support reliable study-specific models. We propose a hierarchical sparse Bayesian multitask logistic regres...