Jahan B. Ghasemi

An integrated graph neural network and structure-based workflow for the discovery of allosteric PCSK9 inhibitors

Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a central role in cholesterol homeostasis by promoting the degradation of low-density lipoprotein receptors (LDLR), making it an attractive therapeutic target for cardiovascular disease. Although monoclonal antibodies an...