Jae Wook Lee

Development and preclinical characterization of an MMAE-conjugated anti-EpCAM antibody–drug conjugate for colorectal cancer

The epithelial cell adhesion molecule (EpCAM) is frequently overexpressed in colorectal cancer (CRC) and thus represents an attractive therapeutic target. However, the clinical efficacy of EpCAM-targeting antibodies has been limited by suboptimal binding properties and reliance o...