Jacob Gable

Distinct sensorimotor encoding in tuft dendrites and somata associated with action, correction, and learning

Frontal cortex plays critical roles in action control and motor skill learning. Within the layer 1 apical tuft dendrites of layer 5 (L5) neurons in the frontal cortex, precise input patterns and back-propagating action potentials can trigger powerful regenerative events that may...

Tuft dendrite spikes are accompanied by selective input from distinct functional networks

The tuft dendrites of layer 5 neurons can support regenerative events - dendritic spikes - that have been proposed to coordinate context-specific engagement and plasticity within cortical networks. However, it remains unclear whether tuft spikes are accompanied by input activity...