Jacinta L. Simmons

Inhibition of BRN2 in melanoma reverses anoikis resistance and sensitizes cells to killing by vemurafenib

Abstract Anoikis is an apoptotic cell death program triggered upon detachment from surrounding extracellular structures. However, the ability to evade cell death by anoikis in the presence of apoptosis-inducing stimuli is necessary for the formation of malignant tumors and progre...