J ZHU

Agonist Binding Reshapes the Kinetic Landscape and Allosteric Communication of APLNR Toward Activation-Competent States

APLNR is a therapeutically important G protein-coupled receptor (GPCR) implicated in cardiovascular and metabolic regulation; however, how agonist binding reorganizes receptor dynamics to promote signaling competence remains poorly understood. Here, we used the small-molecule ago...