J. Thomas Brenna

The Lipid Switch:Ultra-High Dose Omega Fatty AcidsDetermine MYCN Neuroblastoma Fate and Implicate Substrate-LevelOxylipin Competition

Abstract Pediatric neuroblastoma exhibits puzzling biological heterogeneity─some tumors regress spontaneously while high-risk cases resist intensive multimodal therapy─suggesting modifiable determinants of tumor fate beyond genes and proteins. Using a syngeneic MYCN-driven mouse...