J. Patrick O’Connor

A human rheumatoid arthritis bone–cartilage interface organoid recapitulates bone, cartilage, and immune interactions

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation, cartilage degradation, and bone erosion. Fibroblast-like synoviocytes (FLS) play a central role in perpetuating joint damage, yet current therapies inadequately address FLS-driven pa...