J Mirsch

Repair of DNA double-strand breaks after low radiation doses in childhood cancer survivors and matched cancer-free individuals

Abstract DNA double-strand breaks (DSBs) which arise in G1- or G0-phase normal human cells are repaired by non-homologous end-joining (NHEJ), a pathway which is important for cell survival but can cause mutations at the break sites. DSB repair by NHEJ is very efficient at high da...