J. Michael Conlon

Design of Potent, Non-Toxic Antimicrobial Agents Derived from the Frog Skin Peptide Raniseptin-PL Active Against Gram-Negative ESKAPE+ Pathogens

Background/Objectives: The frog skin peptide raniseptin-PL (GVFDTVKKIGKAVGKFALGVAKNYLNS.NH2) is active against a range of antibiotic-resistant bacteria including ESKAPE+ pathogens, but its therapeutic potential is limited by high cytotoxicity against mammalian cells. The study ai...