Izumi Horikawa

Δ133p53α, a senescence-inhibitory p53 isoform, attenuates accelerated aging in progeria mice

Abstract Research on progeria not only contributes to the development of treatments for the disease but also enhances our understanding of physiological aging. In a mouse model of Hutchinson-Gilford progeria syndrome (HGPS), transgenic expression of Δ133p53α, a senescence-inhibit...