Ivan Vilotijević

Accessing Sterically Congested Benzannulated Cyclic Aryl Ethers via Photoredox Decarboxylative Giese-Type C2–C3 Bond Formation

Abstract The visible-light-driven photocatalytic decarboxylation of α-aryloxy carboxylic acids produces α-oxy carbon-centered radicals that undergo intramolecular Giese addition to form 2,3-dihydrobenzofurans, chromans, 2,3,4,5-tetrahydrobenzo[b]oxepines, and 3,4,5,6-tetrahydro-2...

Adenylation Domain Engineering Enables Biosynthesis of an Improved Polymyxin Antibiotic

ABSTRACT Polymyxins are potent nonribosomal peptide antibiotics, yet their clinical use is limited by a narrow therapeutic window and nephro‐/neurotoxicity. Conventional efforts to improve these agents rely on the incorporation of nonnatural building blocks that cannot be accesse...