孙国瑞

BRD4-S reprograms glutathione metabolism to reduce ferroptosis sensitivity and limits oxaliplatin response in gastric cancer

Abstract Background Bromodomain-containing protein 4 (BRD4) exists as distinct isoforms with potentially different biological functions, but their roles in ferroptosis and chemotherapy response in gastric cancer (GC) remain poorly understood. Here, we investigated the isoform-spe...