宁晓暄

CRISPR screening identifies TWIST1 as a ferroptosis driver in CKD progression

Chronic kidney disease (CKD) lacks effective therapeutic interventions targeting its fundamental pathological mechanisms. TWIST1 is a basic helix-loop-helix transcription factor that is a critical regulator in kidney fibrosis pathogenesis. We used genome-wide CRISPR-Cas9 screenin...