平勇

HDAC11 and COMP Modulate Breast Cancer Cell Phenotypes and Osteoclastogenic Responses in a Co-culture Model

Background: Cartilage oligomeric matrix protein (COMP) interacts with stromal interaction molecule 1 (STIM1). Both COMP and histone deacetylase 11 (HDAC11) are highly expressed in breast cancer cells (BCC). Given the reported inhibitory effect of HDAC3 on COMP acetylation, HDAC11...