中何泉

miR-7a-5p attenuates hypoxic-ischemic encephalopathy by suppressing PARP1-mediated parthanatos

Hypoxic-ischemic encephalopathy (HIE) causes severe neonatal brain injury, with PARP1 hyperactivation implicated in neuronal death. Using a rat HIE model and glutamate-exposed HT22 neurons, we found that miR-7a-5p is significantly downregulated in both peripheral blood and the in...