Isadora Leitzke Guidotti

Sequence-Activity Relationships and Integrated In Silico and In Vitro Mechanistic Study of the Antimicrobial Peptide PEP-4 against Staphylococcus aureus

Abstract The rise of antimicrobial resistance among ESKAPE pathogens demands novel therapeutic strategies. Here, we evaluate a panel of five synthetic peptides through integrated in vitro and in silico analyses, highlighting PEP-4 as a promising antibacterial lead peptide. Our fi...