Isabelle Aubry

PTPN2 sustains non-canonical inflammasome activation and shapes the inflammatory response to sepsis

Abstract The innate immune system relies on pattern recognition receptors to recognize and detect pathogens. Gram-negative bacteria release LPS-rich outer membrane vesicles (LPS-OMVs), which activate PRRs, trigger inflammation at distant sites and contribute to systemic inflammat...

PTPN1 and PTPN2 cooperatively set interferon responsiveness thresholds that govern cancer immune evasion

Immune evasion by cancer cells remains a major barrier to the success of immune checkpoint blockade (ICB). In recent years, Protein tyrosine phosphatase non-receptor type 2 (PTPN2) has emerged as a promising and druggable target for cancer immunotherapy. Small-molecule agents cur...