Isaac T. S. Li

Mechanical Signatures of Nucleic Acid Trefoil Knot Topology

Molecular knots represent a fundamental form of polymer topology, yet their mechanical behavior in nucleic acids remains largely unexplored. Here, we engineer a single-stranded DNA sequence that can fold into either a knot or a pseudoknot while maintaining identical base-pairing...

Mechanical Signatures of Nucleic Acid Trefoil Knot Topology

ABSTRACT Molecular knots represent a fundamental form of polymer topology, yet their mechanical behavior in nucleic acids remains largely unexplored. Here, we engineer a single‐stranded DNA sequence that can fold into either a knot or a pseudoknot while maintaining identical base...