Irina S. Moreira

Cholesterol-Enriched Membranes Reshape the Conformational Ensemble and Interfacial Mechanics of ACE2

Abstract Angiotensin-converting enzyme 2 (ACE2) is a type I transmembrane protein that functions as the primary entry receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). ACE2 comprises a zinc-dependent extracellular domain (ECD) and forms homodimers, as res...