Irina Cesnokova

Functional differences of Munc18 isoforms reflect their affinities for the exocytosis site

Abstract The SM-protein Munc18 and its binding partner syntaxin are crucial for two distinct steps of regulated exocytosis, docking of secretory granules at the release site, and priming reactions that prepare docked granules for Ca 2+ dependent fusion. Both proteins cluster simu...