Irina A. Okkelman

Patient-derived models reveal LTBP2-linked collagen I niche that prime adaptive cell plasticity and tune chemoresponse in colorectal cancer

Abstract Background The extracellular matrix (ECM) is a critical component of the tumour microenvironment (TME) and regulates epithelial plasticity and therapeutic responses in colorectal cancer (CRC). However, the mechanisms by which specific ECM components modulate tumour cell...