Ionut Alexandru Stefan

Coupled Epigenetic, Mechanical, Network, and Intestinal Attractors as a Threshold Mechanism for Chronicity in Gut-Driven Axial Spondyloarthritis: A Hypothesis

* Chronic gut-driven axial spondyloarthritis is hypothesized to persist through a coupled four-node systems architecture rather than a single dominant inflammatory pathway. * Four interacting persistence nodes are proposed: epigenetic memory (N1), extracellular matrix stiffening...