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Redox-Dependent Lipophilicity of Phenazine Metabolites Is Modulated by Intramolecular Hydrogen Bonds and Controls Their Biological Distribution

Abstract Phenazines are redox-active microbial metabolites produced and secreted in diverse ecological contexts from soils to chronic infections. Phenazines can function variously as antibiotics, extracellular electron shuttles, and nutrient scavengers. Key to understanding the i...