Ileana Tobías-Juárez

Determinants of Abl kinase stability and drug binding thermodynamics: Role of regulatory domains and phosphorylation

Abstract Activity dysregulation of Abl kinase is the primary cause for chronic myeloid leukemia (CML). Despite extensive characterization, the thermodynamic basis of Abl stability and inhibitor recognition remains incompletely understood. To characterize the cooperative folding o...