Ignacio E. Sánchez

Covalent linkage of the papillomavirus E2 DNA-binding domain reveals a soluble amyloid-like assembly pathway

Abstract Early soluble intermediates in amyloid formation are difficult to characterize because they are transient and obscured by competing insoluble aggregation. Here, we use scE2C, an engineered covalently linked version of the HPV16 E2 DNA-binding dimer, as a tractable model...