Ichiro Kurakazu

IL-15 drives antigen-independent increase in granzyme K+B+ CD8 T cells enriched in rheumatoid arthritis joints

OBJECTIVES: CD8 T cells co-expressing granzymes K and B (GzmK + B+) are enriched in the joint compared with peripheral blood and have been implicated in the pathogenesis of rheumatoid arthritis (RA). However, it remains unclear whether the enrichment of GzmK+B+ subsets is specifi...