Ibrahim Boussaad

Screening Luxembourg's older general population for probable REM sleep behaviour disorder with a nationwide online survey

Abstract REM Sleep Behaviour Disorder (RBD) is a hallmark of the prodromal phase of α-synucleinopathies. We aimed to describe the prevalence of probable RBD and to assess its associations with demographics, cognition, and location in a large sample of older adults in Luxembourg,...

GBA1 mutations as a role model for precision medicine in Parkinson’s disease

Abstract Genetic variants in GBA1 , encoding the lysosomal enzyme glucocerebrosidase (GCase), represent the strongest genetic risk factor for Parkinson’s disease (PD) and provide a mechanistic link between Gaucher disease (GD) and PD. While biallelic GBA1 mutations cause GD, hete...