Hyunkyung Park

Targeting CDK7 to overcome hypomethylating agent resistance in acute myeloid leukemia

Abstract Purpose Hypomethylating agents (HMAs), such as azacitidine and decitabine, are widely used in elderly or medically unfit patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). However, most patients eventually develop primary or acquired resistance...

Integrative stratification of response to immunotherapy using host and microbial signatures in patients with advanced non-small cell lung cancer

Abstract Background The gut microbiome has been linked to responses to immune checkpoint inhibitors (ICIs), yet longitudinal multi-omics studies remain limited. Methods Here, we serially collected gut microbiome data and performed multi-omics analyses, including RNA sequencing (R...