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Affinity-tuned anti-idiotypic masking enables protease-activatable HER2-targeting antibodies with an optimized masked–unmasked dynamic range

Activatable antibodies aim to minimize on-target off-tumor toxicity by suppressing antigen binding through a masking domain that is released only upon encountering a tumor-associated stimulus. Anti-idiotypic single-domain antibodies (dAbs) raised against the complementarity-deter...