Hyojung Paik

Machine learning–driven decoding of maternal immune signatures in repeated pregnancy loss

Repeated pregnancy loss (RPL) is a multifactorial condition in which the underlying immunological mechanisms, particularly the disruption of maternal-fetal tolerance, remain incompletely understood. Although immune tolerance is critical for pregnancy success, the specific immune...

Unfolded protein response signaling promotes myeloid cell production and cooperates with oncogenic mutation

Abstract Unfolded protein response (UPR) promotes protein homeostasis under endoplasmic reticulum stress. UPR signaling has numerous functions in metabolism, cancer, immunology, and neurodegenerative diseases. Recent studies also showed that UPR signaling has important roles in h...