Hye Won Lee

Hospitalisation in cirrhosis is linked to distinct gut microbiome structural and functional profiles: a multinational metagenomic study

Background Hospitalisations represent major clinical events in cirrhosis, yet prediction based on clinical variables alone remains limited. Objective Given the role of the gut microbiome in disease progression, we evaluated whether gut metagenomic profiles are associated with 90-...

Noninvasive surrogate endpoints in MASH trials: current perspectives and challenges

Abstract Background Metabolic dysfunction-associated steatohepatitis (MASH) is a leading cause of cirrhosis and liver-related morbidity. Current regulatory pathways rely on histology and long-term clinical outcomes, but repeated liver biopsy is noninvasive and poorly reproducible...