Hye Seung Lee

Niche-resolved transcriptional programs and ΔNp63/NRF2-associated enrichment in post-chemoradiation esophageal squamous cell carcinoma

Spatial organization in esophageal squamous cell carcinoma resection specimens after chemoradiation remains poorly characterized. We profiled 56 patients using Visium spatial transcriptomics and identified eight niches. All 37 evaluated transcriptional signatures showed marked va...