Hyangsoon Lim

Lobular carcinoma as a spectrum: resolving the gray zone between morphology, E-cadherin, and CDH1

Invasive lobular carcinoma (ILC) is characterized by E-cadherin loss resulting from CDH1 inactivation, but discordance among morphology, immunohistochemistry (IHC), and molecular findings can complicate diagnosis. We integrated histology, IHC, DNA sequencing, and whole-transcript...