HUNTER J. SAVAGE

A Tale of Two Heterocycles: How Oxygen and Sulfur Shape Divergent Kemp Reactivity

ABSTRACT The Kemp elimination is a well‐studied reaction that proceeds through the deprotonation of carbon‐3 of benzisoxazoles, coupled with irreversible ring opening by cleavage of the labile O‐N bond. The base‐catalyzed reaction is concerted, with no detectable intermediate. Du...