Huiru Bi

Inhibition of neuronal DICER–miR-34a/346 signaling attenuates amyloid pathology in 5×FAD mice

MicroRNAs (miRNAs) are critical regulators of genes underlying Alzheimer’s disease (AD) pathogenesis, yet the role of neuronal DICER, a key ribonuclease essential for miRNA maturation, remains unclear. While biochemical analysis of human postmortem cortical tissues revealed upreg...